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Clinical Studies and Resources for Compression Therapy

Clinical Studies & Patient Resources

Explore research and educational resources related to pneumatic compression, lymphedema management, venous-ulcer care, arterial compression, and post-mastectomy patient protections.

Research and medical-information notice

The summaries on this page are brief descriptions of the linked resources and do not replace the complete publications, clinical judgment, device instructions, or individualized medical advice. Read the full source PDF before relying on a study’s methods, limitations, or conclusions.

Research Library

Clinical Studies on Compression Therapy

These resources discuss intermittent pneumatic compression, lymphedema, wound care, venous ulcers, post-mastectomy care, and patient outcomes.

Preview of the IPC and edema fluid movement study
Lymphedema 2025

IPC and Edema Fluid Movement

This study reports that intermittent pneumatic compression may reduce edema fluid in the arm and decrease tissue stiffness. It also discusses early compression therapy in relation to limb enlargement and secondary tissue changes.

Open PDF Study
Preview of the compression therapy and infection-rate study
Lower-Extremity Lymphedema 2021

Compression Therapy and Infection Rates

This study reports an association between lymphedema compression-pump use and reductions in infections and hospitalizations among patients with lower-extremity lymphedema.

Open PDF Study
Preview of the tissue-fluid pressure during compression study
Compression Mechanics

Tissue Fluid Pressure During Compression

This abstract discusses tissue-fluid pressure and flow during pneumatic compression in lower-limb lymphedema and considers how external pressure settings affect tissue-fluid movement.

Open PDF Study
Preview of the intermittent pneumatic compression device review
Clinical Review

Intermittent Pneumatic Compression Device Review

This review discusses different pneumatic compression systems used for lymphedema and emphasizes combining pump therapy with other clinician-directed measures such as garments, elevation, and manual techniques.

Open PDF Study
Preview of the pneumatic compression wound-care study
Venous Ulcers

Pneumatic Compression in Wound Care

This resource reports that a four-chamber pneumatic compression pump and boot were associated with faster wound-size reduction than treatment without a pump.

Open PDF Study
Preview of the overview of lymphedema treatment study
Treatment Planning

Overview of Lymphedema Treatment

This study, co-authored by Linda Miller, PT, supports a multimodal treatment plan that includes compression garments, elevation, exercise, and a lymphedema compression pump.

Open PDF Study
Preview of the sequential pump and venous-ulcer healing study
Venous Ulcers 1990

Sequential Pump and Venous Ulcer Healing

This resource discusses the use of sequential pneumatic compression in venous-ulcer healing.

Open PDF Study
Preview of the pneumatic compression vascular-ulcer study
Vascular Ulcers

IPC for the Treatment of Vascular Ulcers

This study describes outcomes associated with pneumatic compression in venous-ulcer care and reports improvement among the patients studied.

Open PDF Study
Preview of the post-mastectomy lymphedema study
Post-Mastectomy Care 1996

Post-Mastectomy Lymphedema Study

This study reviews the lymphatic system, complications, and treatment options and discusses the combined use of garments, massage, and sequential pneumatic compression.

Open PDF Study
Preview of the limb-volume and quality-of-life study
Patient Outcomes

Limb Volume and Quality-of-Life Study

This study reports that pneumatic compression therapy was associated with reduced limb volume and improved quality of life among many of the patients observed.

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Arterial Compression

Studies for Arterial-Assist Compression

These resources discuss intermittent pneumatic compression in relation to peripheral arterial disease, ischemic pain, walking distance, and arterial-ulcer management.

PLOS ONE • 2019

Long-Term Arterial Assist IPC

This study reports that long-term arterial-assist intermittent pneumatic compression increased toe-capillary flow and extended painless walking distance in the patients studied.

Open PDF Study
Wounds • 2015

High-Pressure IPC for PAD and Critical Limb Ischemia

This randomized controlled trial reports improvements in peak walking time, resting pain, and healing outcomes among patients with peripheral arterial disease and critical limb ischemia.

Open PDF Study
Clinical Review

Treatment of Arterial Ulcers Review

This review discusses high-pressure intermittent calf-and-foot compression for arterial ulcers and ischemic pain and reports a mean reduction in wound surface area in the study population.

Open PDF Study
Patient Rights

Women’s Health and Cancer Rights Act

The Women’s Health and Cancer Rights Act of 1998 provides federal protections when a group health plan or health-insurance issuer covers medical and surgical benefits for a mastectomy. Required mastectomy-related coverage includes:

  • All stages of reconstruction of the breast on which the mastectomy was performed.
  • Surgery and reconstruction of the other breast to produce a symmetrical appearance.
  • Prostheses.
  • Treatment of physical complications of all stages of the mastectomy, including lymphedema.

Coverage is determined in consultation with the attending physician and patient and may be subject to the plan’s applicable deductibles and coinsurance. Health plans must also provide notice describing these protections. Patients should review their plan documents and contact the plan administrator or insurer for benefit details.

Pink ribbon representing breast cancer awareness

Questions About Compression-Therapy Equipment?

Our team can help patients and healthcare professionals understand equipment options, documentation requirements, referrals, and insurance-verification steps.